Udder health effects of an evidence-based mastitis therapy concept in northwestern Germany
Schlagworte:
dairy cow, clinical mastitis, selective mastitis treatment, antibiotic reductionAbstract
Antibiotic use in dairy farming is a highly discussed issue in society. As a result, the European commission issued guidelines for the prudent use of antimicrobial agents in veterinary medicine in 2015 (EU 2015/C 299/04). Several studies could show effects of selective treatment of clinical mastitis. The present study assesses antibiotic reduction without negative effects on cure rates. The mastitis therapy concept was used on a 950-cow dairy farm in northwestern Germany from 2016-2017. The cows showing clinical mastitis were assigned to an examination and a control group. The control group (n=71) was given the standard therapy, an intramammary antibiotic. Cows from the examination group (n=69) were treated, based on their individual mastitis history and the result of a rapid on-farm test of a quarter milk sample. The udder health effects such as clinical cure, bacteriological cure, cytological cure, number of recurrent cases of clinical mastitis, the culling rate as well as the withdrawal period and mean doses of antibiotics were compared between the control and examination group. There was a significantly higher chance of a clinical cure in the examination group (p=0.01, examination group: 43.5%, control group: 21.7%). The cure rate for bacteriological cure was 62.5% for the examination group and 66.6% for the control group. As well, 14.5% of cows had a cytological cure in the examination group and 9.9% of cows in the control group, respectively. However, the mean amount of local antibiotics per case was approximately 55% higher in the control group. Thus, this therapy concept could significantly reduce the antibiotic usage for mastitis treatment without there being any negative effects on cure rates.
Literaturhinweise
Viora L, Graham EM, Mellor DJ, Reynolds K, Simoes PB , Geraghty TE. Evaluation of a culture-based pathogen identification kit for bacterial causes of bovine mastitis. Vet Rec, 2014; 175: 89.
Kuipers A, Koops WJ, Wemmenhove H. Antibiotic use in dairy herds in the Netherlands from 2005 to 2012. J Dairy Sci, 2016; 99(2): 1632–1648.
Mansion-de Vries EM, Lücking J, Wente N, Zinke C, Hoedemaker M, Krömker V. Comparison of an evidence-based and a conventional mastitis therapy concept with regard to cure rates and antibiotic usage. Milk Sci Int, 2016; 69: 27-32.
Roberson JR. Treatment of Clinical Mastitis. Vet Clin N Am-Food A, 2012; 28(2): 271-288.
Lago A, Godden SM, Bey R, Ruegg PL, Leslie K. The selective treatment of clinical mastitis based on on-farm culture results: I. Effects on antibiotic use, milk withholding time, and short-term clinical and bacteriological outcomes. J Dairy Sci. 2011; 94(9): 4441-4456.
Hoe FGH, Ruegg PL. Relationship between antimicrobial susceptibility of clinical mastitis pathogens and treatment outcome in cows. J Am Vet Med Assoc, 2005; 227(9): 1461-1468.
Barlow J. Mastitis therapy and antimicrobial susceptibility: a multispecies review with a focus on antibiotic treatment of mastitis in dairy cattle. J Mammary Gland Biol, 2011; 16(4): 383–407.
Persson Y, Katholm J, Landin H, Mörk MJ. Efficacy of enrofloxacin for the treatment of acute clinical mastitis caused by Escherichia coli in dairy cows. Vet Rec, 2016; 178(10): 240.
Suojala L, Kaartinen L, Pyörälä S. Treatment for bovine Escherichia coli mastitis--an evidence-based approach. J Vet Pharmacol Ther, 2013; 36(6): 521-531.
Degen S, Paduch JH, Hoedemaker M, Krömker V. Factors affecting the probability of bacteriological cure of bovine mastitis. Tierarztl Prax G N, 2015; 43(4): 222-227.
Keefe G, McCarron J, MacDonald K. Using on-farm mastitis culturing. Western Canadian Dairy Seminar, 2011; 23: 81-91.
Grieger AS, Zoche-Golob V, Paduch JH, Hoedemaker M, Krömker V. Rezidivierende klinische Mastitiden bei Milchkühen - Bedeutung und Ursachen. Tierarztl Prax G N, 2014; 42(3): 156–162.
Pinzón-Sánchez C, Ruegg PL. Risk factors associated with short-term post-treatment outcomes of clinical mastitis. J Dairy Sci. 2011; 94(7): 3397-3410.
Østerås O. Mastitis Epidemiology Practical Approaches and Applications. XXIV World Buiatrics Congress, 2006; (3).
McDougall S, Abbeloos E, Piepers S, Rao AS, Astiz S, van Werven T, Statham J, Pérez-Villalobos N. Addition of meloxicam to the treatment of clinical mastitis improves subsequent reproductive performance. J Dairy Sci, 2016; 99(3): 2026–2042.
Krömker V, Paduch JH, Abograra I, Zinke C, Friedrich J. Effects of an additional non-steroidal anti-inflammatory therapy with carprofen (Rimadyl Rind) in cases of severe mastitis of high yielding cows. Berl Munch Tierarztl, 2011; 124 (3-4): 161–167.
Krömker V, Schmenger A, Kock J, Klocke D, Paduch JH, Leimbach S. Aspekte einer modernen Mastitistherapie, Prakt Tierarzt, 2018; 99 (02/2018): 180-189.
International Dairy Federation (IDF). Suggested interpretation of mastitis terminology. Bulletin of the IDF. 1999; 338, Brussels.
Heeschen W, Reichmuth J, Tolle A, Zeidler H. Die Konservierung von Milchproben zur bakteriologischen, zytologischen und hemmstoffbiologischen Untersuchung. Milchwissenschaft, 1969; 24: 729–734
Smith KL. Mastitis control: a discussion. J Dairy Sci, 1983; 66: 1790-1794.
GVA (German Veterinary Association). Leitlinien zur Entnahme von Milchproben unter antiseptischen Bedingungen und Leitlinien zur Isolierung und Identifizierung von Mastitiserregern, 2009; 2nd edition. Gießen, Germany: German Veterinary Association, Friedrichstraße 17, D-35392 Gießen: 1-92
Kock J, Wente N, Zhang Y, Paduch JH, Leimbach S, Krömker V. Accuracy of 12h-Petrifilm plate as a rapid on-farm test for evidence-based mastitis therapy on a dairy farm in Germany. Milk Sci Int, 2018; 71: 10-13.
Leimbach S, Krömker V. Laboratory evaluation of a novel rapid tube test system for differentiation of mastitis-causing pathogen groups. J Dairy Sci. 2018 101(7), 6357-6365
Deluyker HA, van Oye SN, Boucher JF. Factors Affecting Cure and Somatic Cell Count After Pirlimycin Treatment of Subclinical Mastitis in Lactating Cows. J Dairy Sci, 2005; 88 (2): 604-614
GVA (German Veterinary Association). Deutsche Leitlinien Bekämpfung der Mastitis des Rindes, 2012, 5th edition. Gießen, Germany: German Veterinary Association, Friedrichstraße 17, D-35392 Gießen:
McDougall S, Agnew KE, Cursons R, Hou XX, Compton CRW. Parenteral treatment of clinical mastitis with tylosin base or penethamate hydriodide in dairy cattle. J Dairy Sci, 2007; 90(2): 779-789.
Linder M, Paduch JH, Grieger AS, Mansion-de Vries E, Knorr N, Zinke C, Teich K, Krömker V. Heilungsraten chronischer subklinischer Staphylococcus aureus-Mastitiden nach antibiotischer Therapie bei laktierenden Milchkühen. Berl Munch Tierarztl, 2013; 126(7–8): 291–296.
Ranjan R, Swarup D, Patra RC, Nandi D. Bovine protothecal mastitis: a review. CAB Reviews: Perspectives in Agriculture, Veterinary Science, Nutrition and Natural Resources, 2006; 1(17): 1–7.
Jánosi S, Szigeti G, Rátz F, Laukó T, Kerényi J, Tenk M, Katona F, Huszenicza A, Kulcsár M, Huszenicza G. Prototheca zopfii mastitis in dairy herds under continental climatic conditions. Vet Quart, 2001; 23(2): 80–83.
Roberson, JR. Establishing treatment protocols for clinical mastitis. Vet Clin N Am-Food A, 2003; 19: 223-234
Guterbock WM, Van Eenennaam AL, Anderson RJ, Gardner IA, Cullor JS, Holmberg CA. Efficacy of intramammary Antibiotic Therapy for Treatment of Clinical Mastitis caused by Environmental Pathogens. J Dairy Sci, 1993; 76 (11): 3437-3444
Mansion-de Vries EM, Knorr N, Paduch JH, Zinke C, Hoedemaker M, Krömker V. A field study evaluation of PetrifilmTM plates as a 24-h rapid diagnostic test for clinical mastitis on a dairy farm. Prev Vet Med, 2014; 113(4): 620–624.
Trevisi E, Zecconi A, Cogrossi S, Razzuoli E, Grossi P, Amadori M. Strategies for reduced antibiotic usage in dairy cattle farms. Res Vet Sci, 2014; 96(2): 229-233.
